Research Areas
The main research theme is breast cancer. The studies look at how risk factors such as body mass index, family history and metabolic syndrome relate to the molecular subtypes of the tumour; whether inflammatory markers calculated from an ordinary blood count (neutrophil, lymphocyte and platelet ratios) are linked to the course of the disease; and the side effects of hormonal therapy and targeted therapy. Most of this work was carried out during subspecialty training at the medical oncology department of Hacettepe University.
A second group consists of multicentre studies. Two papers, one on adjuvant treatment after surgery for pancreatic cancer and one on the response to targeted therapy in kidney cancer, were published with pooled data from Turkish oncology research groups. A third group is made up of case reports on bile duct cancer, leukaemia and unusual patterns of spread.
Since completing his training, his clinical interest has moved towards comprehensive genomic profiling and the work of the molecular tumour board; congress abstracts in this area have been presented at national and international meetings. The papers on this page show the physician's research interests. Treatment for any individual patient is decided on the basis of guidelines and that patient's own findings.
- Peer-reviewed journal
- A scientific journal in which each article is assessed by independent experts in the field before it is published.
- DOI
- Digital object identifier, a permanent link to an article; the link opens the article page on the journal's website.
- PubMed
- The index of medical literature maintained by the United States National Library of Medicine; most of the journals listed here are indexed in it.
International Peer-Reviewed Articles
The table lists the 26 articles in order of year. Each row gives the title, the topic and a one-sentence summary written for patients, the journal reference and a link. Articles with a DOI link to the journal page; the others link to a PubMed search for the title.
| Year | Title and topic | Journal | Link |
|---|---|---|---|
| 2012 | Prognosis of breast cancer in patients with peritoneal metastasis Breast cancer. Looks at the course of breast cancer that has spread to the lining of the abdomen. | The Breast, 2012;21(3):420-1 | DOI |
| 2012 | Evaluation of cardiac safety of lapatinib therapy for ErbB2-positive metastatic breast cancer Breast cancer, targeted therapy. Assesses the effect of lapatinib on the heart in HER2-positive breast cancer. | Medical Oncology, 2012;29(5):3232-9 | DOI |
| 2012 | Metabolic syndrome and breast cancer: an overview Breast cancer, risk. Reviews the relationship between metabolic syndrome and breast cancer. | Journal of BUON, 2012;17(2):223-9 | PubMed |
| 2012 | Association between family history and clinicopathologic characteristics in 1987 breast cancer patients Breast cancer, family history. Compares tumour features in 1987 patients with and without a family history of breast cancer. | Journal of BUON, 2012;17(4):649-57 | PubMed |
| 2012 | Long-term advanced cholangiocarcinoma survivor with single-agent capecitabine Bile duct cancer. Reports long-term follow-up of advanced bile duct cancer treated with a single oral drug. | Journal of BUON, 2012;17(4):796 | PubMed |
| 2012 | Comparison of clinicopathological characteristics and outcome of younger and older breast cancer patients Breast cancer, age. Compares tumour features in younger and older patients with breast cancer. | Journal of BUON, 2012;17(4):797 | PubMed |
| 2012 | Joint problems in breast cancer patients receiving adjuvant aromatase inhibitor Breast cancer, side effects. Looks at joint symptoms during hormonal therapy with an aromatase inhibitor. | Journal of BUON, 2012;17(4):798-9 | PubMed |
| 2012 | Electrolyte abnormalities due to irinotecan administration in metastatic HER-2 positive breast cancer patients Breast cancer, side effects. Reports changes in blood salts caused by the chemotherapy drug irinotecan. | Journal of BUON, 2012;17(4):800 | PubMed |
| 2013 | Association of breast cancer subtypes and body mass index Breast cancer, risk. Examines the link between body mass index and the subtype of breast cancer. | Tumori Journal, 2013;99(2):129-33 | DOI |
| 2013 | Association between common risk factors and molecular subtypes in breast cancer patients Breast cancer, risk. Asks whether known risk factors differ between the molecular subtypes of breast cancer. | The Breast, 2013;22(3):344-50 | DOI |
| 2013 | Trastuzumab emtansine (T-DM1) for HER2-positive breast cancer Breast cancer, targeted therapy. Reviews the antibody-drug conjugate trastuzumab emtansine in HER2-positive breast cancer. | Current Medical Research and Opinion, 2013;29(4):405-14 | DOI |
| 2013 | Colon involvement in a chronic lymphocytic leukemia patient Leukaemia. Reports involvement of the large bowel in chronic lymphocytic leukaemia. | Journal of BUON, 2013;18(1):291-2 | PubMed |
| 2013 | Frequency of thyroid disease among breast cancer patients Breast cancer, coexisting conditions. Looks at how often thyroid disease is present in patients with breast cancer. | Journal of BUON, 2013;18(1):294-5 | PubMed |
| 2013 | The prognostic impact of obesity on molecular subtypes of breast cancer in premenopausal women Breast cancer, risk. Examines how obesity affects the course of each breast cancer subtype in women before the menopause. | Journal of BUON, 2013;18(2):335-41 | PubMed |
| 2013 | Medullary carcinoma of the breast: a brief report from a tertiary care center Breast cancer, rare type. Reports a single centre's experience of the rare medullary type of breast cancer. | Journal of BUON, 2013;18(3):798 | PubMed |
| 2013 | Impact of obesity on lymph node status in operable breast cancer patients Breast cancer, risk. Looks at whether obesity is linked to lymph node involvement in operable breast cancer. | Journal of BUON, 2013;18(4):824-30 | PubMed |
| 2013 | Fluid rim sign: a new ultrasonographic sign of soft tissue aspergillosis Infection, imaging. Describes an ultrasound sign of fungal infection in patients with a weakened immune system. | Diagnostic and Interventional Radiology, 2013;19(3):237-9 | DOI |
| 2014 | Impact of inflammatory markers on the prognosis of patients with operable breast cancer Breast cancer, inflammatory markers. Examines whether blood-count ratios are linked to outcome in early breast cancer. | Journal of BUON, 2014;19(3):673-80 | PubMed |
| 2014 | A view from young oncologists on clinical trials in Turkey: obstacles and solution proposals Clinical research. Discusses the obstacles facing clinical trials in Türkiye and proposes solutions. | International Journal of Hematology and Oncology (UHOD), 2014;24(1):1-7 | DOI |
| 2014 | Behçet's disease and breast cancer Breast cancer, coexisting conditions. Reports the coexistence of Behçet's disease and breast cancer. | The Breast Journal, 2014;20(5):566-7 | DOI |
| 2015 | The effect of renin-angiotensin-system inhibition on survival and recurrence of N3+ breast cancer patients Breast cancer, other medicines. Looks at whether blood pressure drugs of the RAS inhibitor class affect the course of breast cancer with extensive lymph node involvement. | Journal of BUON, 2015;20(1):50-6 | PubMed |
| 2015 | Serpentine supravenous hyperpigmentation resulting from vinorelbine administration Chemotherapy, side effects. Reports skin darkening along the vein after the chemotherapy drug vinorelbine. | The Breast Journal, 2015;21(3):311-2 | DOI |
| 2015 | Renal cell carcinoma metastatic to the tongue: a case report and review of the literature Kidney cancer. Reports spread of kidney cancer to the tongue and reviews the literature. | Journal of Oral and Maxillofacial Surgery, 2015;73(6):1227-30 | DOI |
| 2015 | Impact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma Pancreatic cancer. Uses multicentre data to examine adjuvant treatment after surgery for pancreatic cancer. | Chinese Journal of Cancer Research, 2015;27(4):408-16 | PubMed |
| 2017 | Is change in hemoglobin level a predictive biomarker of tyrosine kinase efficacy in metastatic renal cell carcinoma? A Turkish Oncology Group study Kidney cancer, targeted therapy. Asks whether a change in haemoglobin predicts response to targeted therapy in kidney cancer. | Cancer Investigation, 2017;35(4):248-55 | DOI |
| 2017 | Prognostic role of inflammatory biomarkers in metastatic breast cancer Breast cancer, inflammatory markers. Examines whether inflammatory markers are linked to the course of metastatic breast cancer. | Journal of BUON, 2017;22(3):614-22 | PubMed |
Please note: The results of these studies are population data and are not treatment recommendations on their own. Treatment is chosen by the physician on the basis of stage, pathology and molecular findings for each individual patient.
Internal Medicine Intern Case Seminar
A post from the Internal Medicine Intern Case Seminar at Izmir Tinaztepe University.
National Publications and Congress Abstracts
Thirteen abstracts have been presented at international scientific meetings. Twelve were presented at the annual meetings of the American Society of Clinical Oncology (ASCO) in 2009, 2011, 2012 and 2013 and published in the meeting supplement of the Journal of Clinical Oncology; one was presented at the 2011 congress of the European Federation of Internal Medicine (EFIM). The topics were body mass index, blood group, inflammatory markers and short-course trastuzumab in breast cancer. A further abstract on the clinical use of advanced molecular analysis in lung cancer was presented at the 2017 ASCO annual meeting (DOI).
National publications include a case report in the Gaziantep Medical Journal and two chapters (metastatic breast cancer; special situations in breast cancer) in the Turkish edition of the MD Anderson manual of medical oncology, published by Nobel Tıp Kitabevi in 2014. The two abstracts that received awards at Turkish national congresses are described, with their topics, on the awards and memberships page.
Clinical Trials and Patient Participation
A clinical trial is a study in which a new drug or treatment schedule is tested in patients under defined rules and with ethics committee approval. Participation is voluntary and depends on the patient's written consent; a patient may withdraw at any time without losing access to standard treatment. Whether a patient is suitable for a trial is a matter for assessment only; no promise is made that a particular trial will be available. Current trials and the process for off-label applications in Türkiye are discussed, with dates, in the blog.
How to Access the Papers
The full text of each article is available from the journal page. Some journals require a subscription for the full text, but the abstract is always free to read. A PubMed search for the author name Petekkaya I lists the abstracts of all indexed articles, and a DOI link opens the article page on the journal's website directly.
If you would like to relate a paper to your own diagnosis, you can bring the abstract to your consultation; the physician will explain whether and how the study applies to your situation. His training and current post are described on the Prof. Dr. H. Ibrahim Petekkaya page.
Frequently Asked Questions
Where is the full publication list?
All 26 articles in international peer-reviewed journals are listed in the table on this page with year, journal and a link. Articles with a DOI link directly to the journal page; the others link to a PubMed search for the title. Congress abstracts and book chapters are listed under a separate heading. The same articles can be found on PubMed by searching for the author name Petekkaya I. ORCID and Google Scholar profile links will be added here once they are set up.
Which cancer types does the research cover?
Most of the articles are about breast cancer: risk factors, molecular subtypes, inflammatory blood markers, and the side effects of hormonal and targeted therapy. Other papers report multicentre data on pancreatic cancer and kidney cancer, and case reports on bile duct cancer, leukaemia and unusual sites of spread. One paper discusses the obstacles facing clinical trials in Türkiye. Later congress work concerns molecular profiling in lung cancer.
What do these papers mean for patients?
The papers show which questions the physician has studied; they are not treatment recommendations. Treatment decisions follow current ESMO and NCCN guidelines together with the patient's own pathology and molecular findings, and the result of a single study is not applied directly to an individual. Each entry in the table carries a one-sentence summary written for patients, so that you can see what the paper looked at without reading the abstract.
Where are citation metrics shown?
Citation counts, meaning the number of times a paper has been cited by other papers, are not published on this page. They can be looked up in Google Scholar, Web of Science or Scopus by searching for the article title; journal pages reached through a DOI link usually show them as well. Citation counts reflect the academic reach of a study, not the physician's clinical practice, and they are not a measure of treatment quality.
How often is this list updated?
The list is updated when something changes rather than on a fixed calendar. When a new article, abstract or book chapter is published, the page is reviewed within 30 days and the last-updated date is changed. Corrections to links or spelling do not change the date. The last-updated line at the top of the page shows when the list was last checked, and the same date appears in the page's structured data.
Related Pages
Prof. Dr. H. Ibrahim Petekkaya
Open the Page
Awards and Memberships
Open the Page
Press and Interviews
Open the Page
Comprehensive Genomic Profiling
Open the Page
Molecular Tumour Board
Open the Page
Blog
Open the PageSources and Guidelines
- PubMed. Author search: Petekkaya I [Author]. National Library of Medicine. Link
- Google Scholar. Academic article and citation search. Link
- ORCID. Researcher identifier registry. Link
- Crossref. DOI resolution and article metadata. Link
- ClinicalTrials.gov. Registry of clinical studies, United States National Library of Medicine. Link
- Turkish Society of Medical Oncology. Patient information on clinical trials. Link